Journal of Dental Sciences
Volume 5, Issue 2 , Pages 100-108 , June 2010

In vivo evaluation of poorly crystalline hydroxyapatite-based biphasic calcium phosphate bone substitutes for treating dental bony defects

  • Mao-Shuan Huang

      Affiliations

    • Division of Oral and Maxillofacial Surgery, Department of Dentistry, Sin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan
    • Dental Department, Taipei Medical University-Shuang Ho Hospital, Taipei, Taiwan
    • School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
    • ,
  • Hong-Da Wu

      Affiliations

    • School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
    • ,
  • Nai-Chia Teng

      Affiliations

    • School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
    • Dental Department, Taipei Medical University Hospital, Taipei, Taiwan
    • ,
  • Bou-Yue Peng

      Affiliations

    • School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
    • Dental Department, Taipei Medical University Hospital, Taipei, Taiwan
    • ,
  • Jia-Yo Wu

      Affiliations

    • School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
    • Dental Department, Taipei Medical University Hospital, Taipei, Taiwan
    • ,
  • Wei-Jen Chang

      Affiliations

    • Dental Department, Taipei Medical University-Shuang Ho Hospital, Taipei, Taiwan
    • School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
    • ,
  • Jen-Chang Yang

      Affiliations

    • Graduate Institute of Biomedical Materials and Engineering, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
    • ,
  • Chien-Chung Chen

      Affiliations

    • Graduate Institute of Biomedical Materials and Engineering, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
    • Chien-Chung Chen and Sheng-Yang Lee contributed equally to this work.
    • Corresponding Author InformationCorresponding authors. Chien-Chung Chen: Graduate Institute of Biomedical Materials and Engineering, College of Oral Medicine, Taipei Medical University, 250, Wu-Hsing Street, Taipei 11042, Taiwan; Sheng-Yang Lee: School of Dentistry, College of Oral Medicine, Taipei Medical University, 250, Wu-Hsing Street, Taipei 11042, Taiwan
    • ,
  • Sheng-Yang Lee

      Affiliations

    • School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
    • Dental Department, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan
    • Chien-Chung Chen and Sheng-Yang Lee contributed equally to this work.
    • Corresponding Author InformationCorresponding authors. Chien-Chung Chen: Graduate Institute of Biomedical Materials and Engineering, College of Oral Medicine, Taipei Medical University, 250, Wu-Hsing Street, Taipei 11042, Taiwan; Sheng-Yang Lee: School of Dentistry, College of Oral Medicine, Taipei Medical University, 250, Wu-Hsing Street, Taipei 11042, Taiwan

Received 4 February 2010 ,Accepted 21 May 2010.

References 

  1. Ilan DI , Ladd AL . Bone graft substitutes . Oper Tech Plast Reconstr Surg . 2003;9:151–160
  2. Williams A , Szabo RM . Bone transplantation . Orthopedics . 2004;27:488–495
  3. Garg AK . Bone Biology, Harvesting, Drafting for Dental Implant; Rationale and Clinical Applications . Chicago: Quintessence; 2004;
  4. Rack A , Knabe C , Stiller M , et al.   Synchrotron-tomography for evaluation of bone tissue regeneration using rapidly re-sorbable bone substitute materials. e-J Destr Test, 2006; 11 . Available at: http://www.ndt.net/article/ecndt2006/doc/Th.1.2.2.pdf [Accessed: November 2006]
  5. Knabe C , Houshmand A , Berger G , et al.   Effect of rapidly resorbable bone substitute materials on the temporal expression of the osteoblastic phenotype in vitro . J Biomed Mater Res A . 2008;84:856–868
  6. Branemark PI . Osseointegration and its experimental background . J Prosthet Dent . 1983;50:399–410
  7. Jalota S , Bhaduri SB , Tas AC . In vitro testing of calcium phosphate (HA, TCP, and biphasic HA-TCP) whiskers . J Biomed Mater Res A . 2006;78:481–490
  8. Nery EB , LeGeros RZ , Lynch KL , Lee K . Tissue response to biphasic calcium phosphate ceramic with different ratios of HA/beta TCP in periodontal osseous defects . J Periodontol . 1992;63:729–735
  9. LeGeros RZ . Calcium phosphate-based osteoinductive materials . Chem Rev . 2008;108:4742–4753
  10. Szabo G , Huys L , Coulthard P , et al.   A prospective multi-center randomized clinical trial of autogenous bone versus beta-tricalcium phosphate graft alone for bilateral sinus elevation: Histologic and histomorphometric evaluation . Int J Oral Maxillofac Implants . 2005;20:371–381
  11. Pearce AI , Richards RG , Milz S , Schneider E , Pearce SG . Animal models for implant biomaterial research in bone: a review . Eur Cell Mater . 2007;13:1–10
  12. Tamai N , Myoui A , Tomita T , et al.   Novel hydroxyapatite ceramics with an interconnective porous structure exhibit superior osteoconduction in vivo . J Biomed Mater Res . 2002;59:110–117
  13. Jin QM , Takita H , Kohgo T , Atsumi K , Itoh H , Kuboki Y . Effects of geometry of hydroxyapatite as a cell substratum in BMP-induced ectopic bone formation . J Biomed Mater Res . 2000;52:491–499
  14. Oonishi H , Hench LL , Wilson J , et al.   Comparative bone growth behavior in granules of bioceramic materials of various sizes . J Biomed Mater Res . 1999;44:31–43
  15. Tischler M , Misch CE . Extraction site bone grafting in general dentistry: review of applications and principles . Dent Today . 2004;23:1–7
  16. Yamamichi N , Itose M . In: Sinus Floor Elevation . Tokyo: Quintessence; 2008;p. 18–20
  17. Jung YS , Lee SH , Park HS . Decompression of large odontogenic keratocysts of the mandible . J Oral Maxillofac Surg . 2005;63:267–271
  18. Horch HH , Sader R , Pautke C , Neff A , Deppe H , Kolk A . Synthetic, pure-phase beta-tricalcium phosphate ceramic granules (Cerasorb) for bone regeneration in the reconstructive surgery of the jaws . Int J Oral Maxillofac Surg . 2006;35:708–713
  19. Sun W , Zhang F , Guo J , Wu J , Wu W . Effects of amorphous calcium phosphate on periodontal ligament cell adhesion and proliferation in vitro . J Med Biol Eng . 2008;28:107–112

PII: S1991-7902(10)60014-1

doi: 10.1016/S1991-7902(10)60014-1

Journal of Dental Sciences
Volume 5, Issue 2 , Pages 100-108 , June 2010

Article Tools