Journal of Dental Sciences
Volume 5, Issue 2 , Pages 60-69, June 2010

Potential biomarkers for the cytologic diagnosis of oral squamous cell carcinoma

  • Wei-Chung Vivian Yang

      Affiliations

    • Graduate Institute of Biomedical Materials and Engineering, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
    • Corresponding Author InformationCorresponding author: Graduate Institute of Biomedical Materials and Engineering, College of Oral Medicine, Taipei Medical University, 250 Wu-Xing Street, Taipei 11042, Taiwan
    • ,
  • Ho-Ren Chung

      Affiliations

    • School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
    • ,
  • Jia-Yo Wu

      Affiliations

    • School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
    • Department of Dentistry, Taipei Medical University Hospital, Taipei, Taiwan
    • ,
  • Chen Yi

      Affiliations

    • School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
    • ,
  • Duen-Jeng Wang

      Affiliations

    • School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
    • ,
  • Sheng-Yang Lee

      Affiliations

    • School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan

Received 3 February 2010; accepted 10 April 2010.

Unlike other deep cancers, oral squamous cell carcinoma (OSCC), which occurs in the oral cavity, is more easily monitored, and specimens for diagnosis are easier to collect. However, identifying reliable and sensitive markers for the early diagnosis and markers for identification of the recurrence of OSCC remains a challenge. This article mainly focused on reviewing recently identified potential biomarkers for a cytologic diagnosis during OSCC development. In addition, markers used in modern diagnostic technologies, including a sensitive labeling method and a photodynamic approach for cytologic diagnosis, are also described. Cytologic examinations using sensitive and specific biomarkers can improve the accuracy of the diagnosis. Hence, they can lead to appropriate treatment without delay and to the reduced recurrence of OSCC.

Key Words:  biomarkers , cytologic diagnosis , oral squamous cell carcinoma

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PII: S1991-7902(10)60010-4

doi:10.1016/S1991-7902(10)60010-4

Journal of Dental Sciences
Volume 5, Issue 2 , Pages 60-69, June 2010

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