Journal of Dental Sciences
Volume 4, Issue 2 , Pages 45-54, June 2009

The role of hypochlorous acid as one of the reactive oxygen species in periodontal disease

  • Chong-Hou Sam

      Affiliations

    • School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
    • ,
  • Hsein-Kun Lu

      Affiliations

    • Clinical Periodontics, Department of Dentistry, Taipei Medical University Hospital, Taipei, Taiwan
    • Corresponding Author InformationCorresponding author. School of Dentistry, College of Oral Medicine, Taipei Medical University, and Clinical Periodontics, Department of Dentistry, Taipei Medical University Hospital, 250, Wu-Xing Street, Taipei 11042, Taiwan

Received 20 January 2009; accepted 6 April 2009.

Article Outline

Hypochlorous acid (HOCl) has both proinflammatory and anti-inflammatory properties, and seems to play an important role in the immune system. The regulation of normal flora contributes to periodontal health, and HOCl seems to have the ability to attack Gram-negative pathogens during periodontitis. Furthermore, high concentrations of HOCl promote healing by regulating cytokines and growth factors, killing pathogens through chlorination or oxidation, and modulating inflammation through the effects on nuclear factor κB and activator protein-1 of monocytes. After chlorination of taurine by HOCl, taurine chloramine is mostly an anti-inflammatory agent and enhances healing. Neither HOCl nor taurine chloramine are common in clinical applications owing to a lack of studies in animal and human models. Both compounds may be suitable as periodontal medication, as they are good antimicrobial agents, inflammation modulators, and healing promoters.

KEY WORDS:  hypochlorous acid , NF-κB , periodontitis , taurine chloramine , transcription factor AP-1

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PII: S1991-7902(09)60008-8

doi:10.1016/S1991-7902(09)60008-8

Journal of Dental Sciences
Volume 4, Issue 2 , Pages 45-54, June 2009

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