Journal of Dental Sciences
Volume 4, Issue 1 , Pages 13-17 , March 2009

Upregulation of lysyl oxidase expression in cyclosporin A-induced gingival overgrowth

  • Chung-Hung Tsai

      Affiliations

    • Department of Pathology, Chung Shan Medical University Hospital, Taichung, Taiwan
    • Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
  • ,
  • Tsai-Yu Chang

      Affiliations

    • Graduate School of Dentistry, Chung Shan Medical University, Taichung, Taiwan
  • ,
  • Yu-Chao Chang

      Affiliations

    • Graduate School of Dentistry, Chung Shan Medical University, Taichung, Taiwan
    • Department of Periodontics, Chung Shan Medical University Hospital, Taichung, Taiwan
    • Corresponding Author InformationCorresponding author. School of Dentistry, Chung Shan Medical University, No. 110, Chien-Kuo North Road, Section 1, Taichung 40201, Taiwan

Received 4 November 2008 ,Accepted 24 January 2009.

References 

  1. Hassell T , Hefti AF . Drug-induced gingival overgrowth: old problem, new problem . Crit Rev Oral Biol Med . 1991;2:103–137
  2. Pernu HE , Pernu LM , Huttunen KR , Nieminen PA , Knuuttila ML . Gingival overgrowth among renal transplant recipients related to immunosuppressive medication and possible local background factors . J Periodontol . 1992;63:548–553
  3. King GN , Fullinfaw R , Higgins TJ , Walker RG , Francis MD , Wiessenfeld D . Gingival hyperplasia in renal allograft recipients receiving cyclosporine-A and calcium antagonists . J Clin Periodontol . 1993;20:286–293
  4. Mariani G , Calastrini C , Carinci F , Marzola R , Calura G . Ultrastructural features of cyclosporin A-induced gingival hyperplasia . J Periodontol . 1993;64:1092–1097
  5. Marshall RI , Bartold PM . A clinical review of drug-induced gingival overgrowths . Aust Dent J . 1999;44:219–232
  6. Seymour RA , Ellis JS , Thomason JM . Risk factors for drug-induced gingival overgrowth . J Clin Periodontol . 2000;27:217–223
  7. Lin HJ , Tsai CH , Huang FM , Chang YC . The upregulation of type I plasminogen activator inhibitor in human gingival fibroblasts stimulated with cyclosporin A . J Periodontal Res . 2007;42:39–44
  8. Tsai CH , Yang SF , Huang FM , Chang YC . The upregulation of cystatin C in human gingival fibroblasts stimulated with cyclosporin A . J Periodont Res . 2008;
  9. Kagan HM . Lysyl oxidase: mechanism, regulation and relationship to liver fibrosis . Pathol Res Pract . 1994;190:910–919
  10. Smith-Mungo LI , Kagan HM . Lysyl oxidase: properties, regulation and multiple functions in biology . Matrix Biol . 1998;16:387–398
  11. Kosonen T , Uriu-Hare JY , Clegg MS , Keen CL , Rucker RB . Incorporation of copper into lysyl oxidase . Biochem J . 1997;327:283–289
  12. Kagan HM , Trackenman PC . Properties and function of lysyl oxidase . Am J Respir Cell Mol Biol . 1991;5:206–210
  13. Chanoki M , Ishii M , Kobayashi H , et al.   Increased expression of lysyl oxidase in skin with scleroderma . Br J Dermatol . 1995;133:710–715
  14. Goto Y , Uchio-Yamada K , Anan S , Yamamoto Y , Ogura A , Manabe N . Transforming growth factor-ß1 mediated up-regulation of lysyl oxidase in the kidneys of hereditary nephrotic mouse with chronic renal fibrosis . Virchows Arch . 2005;447:859–868
  15. Ma RH , Tsai CC , Shieh TY . Increased lysyl oxidase activity in fibroblasts cultured from oral submucous fibrosis associated with betel nut chewing in Taiwan . J Oral Pathol Med . 1995;24:407–412
  16. Trivedy C , Warnakulasuriya KAAS , Hazarey VK , Tavassoli M , Sommer P , Johnson NW . The upregulation of lysyl oxidase in oral submucous fibrosis and squamous cell carcinoma . J Oral Pathol Med . 1999;28:246–251
  17. Hong HH , Uzel MI , Duan C , Sheff MC , Trackman PC . Regulation of lysyl oxidase, collagen, and connective tissue growth factor by TGF-ß1 and detection in human gingiva . Lab Invest . 1999;79:1655–1667
  18. Hallmon WW , Rossmann JA . The role of drugs in the patho-genesis of gingival overgrowth: a collective review of current concepts . Periodontol 2000 . 1999;21:176–196
  19. Trackman PC , Kantarci A . Connective tissue metabolism and gingival overgrowth . Crit Rev Oral Biol Med . 2004;15:165–175
  20. Trackman PC , Graham RJ , Bittner HK , Carnes DL , Gilles JA , Graves DT . Inflammation-associated lysyl oxidase protein expression in vivo, and modulation by FGF-2 plus IGF-1 . Histochem Cell Biol . 1998;110:9–14
  21. Tang SS , Trackman PC , Kagan HM . Reaction of aortic lysyl oxidase with beta-aminopropionitrile . J Biol Chem . 1983;258:4331–4338
  22. Riley DJ , Kerr JS , Berg RA , et al.   ß-Aminopropionitrile prevents bleomycin-induced pulmonary fibrosis in the hamster . Am Rev Respir Dis . 1982;125:67–73
  23. Ledwozyw A . The effect of ß-aminopropionitrile on bleo-mycin-induced lung injury in rats . Acta Physiol Hung . 1995;83:91–99

PII: S1991-7902(09)60003-9

doi: 10.1016/S1991-7902(09)60003-9

Journal of Dental Sciences
Volume 4, Issue 1 , Pages 13-17 , March 2009